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Although in our study, feeding with DGLA (0.3 mM) induced ferroptosis and shortened the lifespan in worms, a previous study found that exposure to lower level of DGLA (10 M) induced autophagy and increased worm lifespan 65

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Targeting GPX4 and NRF2 pathways, which regulate antioxidant defenses, may provide effective strategies to mitigate ferroptosis and its pathological effects in SLE