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Targeting ferroptosis protects against experimental (multi) organ dysfunction and death

In mice sensitized with ovalbumin, AKR1B1 inhibition with fidarestat prevented the airway remodeling observed in chronic asthma by blocking the tumor growth factor (TGF), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Protein kinase B (PKB/AKT)/Glycogen synthase kinase-3 beta (GSK3B) axis (Yadav et al., 2013b)

PMID: 171 DuanXCPengLYYaoXXuMQLiHZhangSQet al

The page lists indications including chronic inflammation or immune dysregulation, neuroinflammatory conditions, mold or biotoxin exposure related illness, chronic fatigue or post infectious syndromes, respiratory inflammation or vascular dysfunction, gut inflammation or dysbiosis, and nervous system stress and regulatory imbalance

and (ii) May occur only in facilities on the hospital's main campus

So I wanna ask you, you know, in terms of you, you've, we've talked a little bit about mitochondrial health, but inflammation, talk to us about the role of inflammation and infertility