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Ligand preparation was performed to optimize the polyphenol structures for docking using software Maestro 12.5

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doi:10.1007/s13197-013-1047-2

In many cases, profound hypotension develops intraoperatively after 45 to 60 minutes as a result of decreased vascular responsiveness and decreased myocardial contractility and is often refractory to interventions such as fluid or vasopressor therapy.8, 18, 19 Whichever surgical procedure is chosen, it is clear that anesthesia time should be minimized and long-term medical management will be necessary