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When telomeres become critically short: Cells stop dividing Tissue regeneration declines Senescent cells accumulate Aging accelerates Researchers consider telomere shortening one of the fundamental hallmarks of aging

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In other words, there is no toxic dose officially recognized for vitamin B12, a testament to its potential safety

Accordingly, short-term exposure captures transient repair responses, while prolonged delivery permits stable metabolic and transcriptional remodeling of aging neural circuits

10.1016/j.ebiom.2023.104494 9 ChenM.WeiS.WuX.XiangZ.LiX.HeH.et al (2024)