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Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Mazzulli J.R., Xu Y.H., Sun Y., Knight A.L., McLean P.J., Caldwell G.A., Sidransky E., Grabowski G.A., Krainc D

da Silva, D

Its linked to higher homocysteine levels , a risk factor for heart disease, neural tube defects, and pregnancy complications [4]

Sci Total Environ 852

These include elevated levels of pro-inflammatory cytokines in the blood, disruptions in myelogenesis and lymphogenesis, and compromised physical barriers like the intestinal epithelium and the blood-brain barrier (BBB) [11,12,13,14,15]