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Topical application of PEPITEM not only reduced local inflammation but also had systemic effects, such as reducing disease-related splenomegaly and limiting the expansion of CD4+, CD8+, Th1, and Th17 T-cell populations in the spleen

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A: It can cause mild water retention in some patients, usually noticed as slight swelling in the fingers or ankles

The attractive therapeutic strategies include the use of glutamine depletion, glutamine uptake inhibitors, glutamine antagonists/analogues, and GLS inhibitors

doi: 10.1016/0006-2952(78)90184-3