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By its upstream action of inhibiting lipid peroxidation, GPX4 can indirectly but effectively reduce the expression levels of these destructive enzymes, thereby delaying or preventing ECM breakdown (Xiao et al., 2024) (Figure 1)
[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Miroczuk-Chodakowska I., Witkowska A.M., Zujko M.E
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Similar results were observed in the profile of the enzyme glutathione peroxidase (GPX
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2009) and the lower glutamate metabolism may reflect reduced glutamate uptake or impaired general metabolic capacity of astrocytes
