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Mesencephalic astrocyte-derived neurotrophic factor (MANF) mitigates protein oxidation and restores phagocytosis mediated by E3 ligase activity, thereby promoting the survival of BC cells under glucose starvation [106]

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The review synthesized findings from cell-culture experiments (human dermal fibroblasts, keratinocytes, irradiated fibroblasts), animal models (rats, mice, pigs, dogs), and human cosmetic-science studies of topical formulations