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For age-related considerations, creatine for older adults may require adjusted dosing and timing strategies to support energy metabolism

10.1016/j.cmet.2014.10.006 52 KoethR

These findings are complemented by the identification of several single-nucleotide polymorphisms (SNP) in GKRP, the protein that inhibits and sequesters GCK during fasting, that strongly associate with lower fasting glucose and insulin resistance coupled with increased blood and liver TAGs (243, 296)

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Sep 2014;94(5):558-62

With this being said, to achieve the level of enhanced muscle performance and recovery associated with supplemental creatine doses, you would need to consume an amount of animal protein that is thoroughly uncomfortable for most people