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In the anagen phase, the hair is firmly anchored in the scalp and the hair follicles are deeply embedded in the dermis, supplied by blood vessels that provide the necessary nutrients for hair growth

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The change in neuronal signal transduction caused by peripheral nerve injury is an important pathological basis for the occurrence and continuous progress of NP, in which the abnormal expression of pain sensors is the main factor, especially the change in the expression of sensory neurons in the DRG of the pain upload pathway [97,98]
In addition, there are other treatment methods such as targeted therapy and immunotherapy, which target specific molecules of tumor cells or stimulate the patient's own immune system to fight cancer(Lakes et al., 2023)
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When referring to their physicochemical properties, another limitation is their poor solubility at high concentrations
