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To account for T 2 -weighting differences, PRESS water spectra were also collected using both echo times (echo time=122 or 68 ms, repetition time=2,000 ms, free induction decay points=2,048, spectral width=2,000 Hz, number of averages=8)

doi: 10.1126/science.1104742

The cysts grew progressively larger as did kidney volume with vast majority of mutants not surviving past 12 months of age

OTA impairs the antioxidant defense of the cells making them more susceptible to oxidative damage [62] and a reduction in cellular antioxidant defense may contribute to the production of OTA-dependent oxidative damage [76]

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The effectiveness of CR to prolong lifespan and to reduce the risk of age-associated diseases is widely recognized