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ApoE2, ApoE3, and ApoE4 differentially stimulate APP transcription and A secretion

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The inner cell mass (ICM, giving rise to the fetus ) have been found to carry higher methylation than the trophectoderm (TE, giving rise to the placenta )

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Therefore, the use of several sub-strains of mice is a strength of this study [49, 50], and suggests that our findings are more likely to generalize to other mouse sub-strains than they would have if the study were conducted in only one strain of mice