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glutathione depletion-methylation block in cfs depletion induces ferroptosis, autophagy, and premature cell senescence retinal pigment epithelial cells Frontiers | Myalgic Encephalomyelitis/Chronic Fatigue
Description
Collectively, our results highlight the limitation of APR-246 as a p53-rescuing drug because of its overwhelming off-target effects on the redox system at doses that are sufficient to induce ferroptosis but insufficient to rescue mutant p53.

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