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1 2 Critical Reviews in Food Science and Nutrition

Similar content being viewed by others Introduction The presence of the blood-brain barrier (BBB), a tightly interconnected network of blood vessels and endothelial cells that restricts the entry of foreign particles larger than 100 nm into the brain, poses considerable challenges and complexities in advancing therapeutic strategies for neurodegenerative diseases (NDs) 1

Most of the effort has been so far devoted to the identification of medications capable to revert the worst and life-threatening complications of COVID-19, namely cytokine storm and hypercoagulation (Kowalewski et al., 2020

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Originally studied for its profound cytoprotective and gut-healing effects, its potential applications have expanded dramatically in preclinical research