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These PLGA NPs possessed a higher antitumor activity against GBM compared with free drugs (paclitaxel and methotrexate)

Acknowledgments The authors acknowledge BioRender for images

Preparation of treatment and vehicle solutions for cerebrovascular uptake Solutions were made fresh from the same stocks on the day of each treatment

Propofols calming, sedating, and anaesthetic mechanism is due to its prolongation of the action of -aminobutyric acid (GABA), the brains primary inhibitory neurotransmitter [152]

Additional information Supported in part by U.S

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