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Health Care Management Science 23, 482506

Also known as a Jarisch Herxheimer reaction, this type of reaction was discovered when two dermatologists, Adolph Jarisch and Karl Herxheimer found that some individuals undergoing an antibiotic regimen for syphilis started to experience a skin reaction in response (1)

Huang, J

Overdose: No severe outcomes are reported, but high doses may lead to increased fatigue or mild nausea

doi: 10.1007/BF00262746 244 EarhartRHKoellerJMDavisHL

A rodent-based thyroid boxed warning carries no human signal at trial resolution, with a personal or family history of medullary thyroid cancer or MEN2 as a contraindication