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Finally, fentanyl (potent opioid agonist) mainly acts on MORs and has been demonstrated to relieve pain in fibromyalgia patients [202]

Kim JW, Tchernyshyov I, Semenza GL, Dang CV

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NAC has an established safety profile, is readily available and easy to administer, and has a favourable tolerability profile, therefore making it an attractive adjunctive therapy
