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Association between acid-lowering agents, metformin, and vitamin B12 among Boston-area Puerto Ricans

For reference, this is substantially higher than the equivalent human doses typically used

The short answer is: yes, it is possible in specific circumstances, but it is not guaranteed for everyone

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However, such long-lasting phenotypic changes observed in somatic cells can only be sustained when an epigenetic stabilization of gene transcription or programming occurs in cells that are capable of self-renewing, are multipotent, and are required for organ development and regeneration [33]