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43 Although the cause of calcified nodule formation is not fully understood, mechanical stress on the endothelium is thought to contribute

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doi: 10.1093/gerona/58.11.b970

Takeshi Kitai, Kobe City Medical Center General Hospital, Japan Updates Copyright 2022 Rahman, Islam, -Or-Rashid, Mamun, Rahaman, Islam, Meem, Sutradhar, Mitra, Mimi, Emran, Fatimawali, Idroes, Tallei, Ahmed and Cavalu

For example, berberine specifically, downregulates hepatic FMO3 via FXR/SHP signaling and inhibits microbial CutC activity, thereby reducing both microbial TMA generation and hepatic oxidation to TMAO [47, 55, 56], while specific probiotic strainssuch as Bifidobacterium and other butyrate producerscan displace TMA-generating taxa [43]

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