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There is also always the concern that peripheral biomarkers may not reflect what is happening in the CNS [168]
For instance, NAD + levels and mitochondrial function have been shown to decline in sarcopenia muscle in one cohort 249 , while another study did not observe a difference in NAD + levels in sarcopenic muscle, and even NR supplementation had no effect on NAD + levels 262

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Three transcripts were discriminative: the expression of genes encoding a leucine-rich protein, a xyloglucan transglycosylase and a GST was much higher in the resistant species ( C

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