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Due to its potential positive effects, it is considered as a dietary supplement in numerous diseases of the nervous system, for example, in neurodegenerative diseases (Parkinsons diseases, amyotrophic lateral sclerosis (ALS), Friedreichs ataxia) and in multiple sclerosis (MS) [71,75]

Omran B, Baek K

The dsRNA replicative intermediate is a potent pathogen-associated molecular pattern (PAMP) sensed by pattern recognition receptors (PRRs) in the cytoplasm (RIG-I-like receptors (RLRs)) and the endosome (Toll-like receptor 3 (TLR3))

Furthermore, the in vivo efficacy, safety, and biodistribution of AuNPs-TMC/siRNA nanocomplexes together with bio-imaging and phototherapy properties should be taken into account in future work to achieve a novel formulation with sufficient efficacy and low adverse effects

Agaricus bisporus (Mushroom) Agaricus bisporus (Agaricaceae) is familiarly known as the button mushroom