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Description
In melanoma, low glutamine in the tumour core led to the depletion of -ketoglutarate (KG), a key cofactor for the Jumonji-domain-containing histone demethylases (JHDMs), which catalyse the removal of methyl marks from histones 1,7
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More rarely lymphocytopenia may be caused by some types of chemotherapy or malignancies
Banasavadi-Siddegowda, Y
In addition, 2-3 different enzymes are used by our scientists to digest protein samples, thus improving the sequence coverage of histone MS peptide maps to identify more PTM sites
