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Treatment Protocol Begin with conservative dosing (200-300 mcg daily or 500 mcg twice weekly) and titrate based on response

Another approach of TNF- pathway blockade that has been recently examined is the development of orally active small molecules (such as UCB-9260) that destabilize TNF- trimer, impeding TNF--TNFR1 binding and signaling [200]

doi: 10.1038/nature05026

doi: 10.1038/sc.2014.147

[DOI] [PubMed] [Google Scholar] Blankenship RE, Tiede DM, Barber J, Brudvig GW, Fleming G, Ghirardi M, Gunner MR, Junge W, Kramer DM, Melis A, Moore TA, Moser CC, Nocera DG, Nozik AJ, Ort DR, Parson WW, Prince RC, Sayre RT

It's a game-changer in healthcare, and it's all about using the body's natural ability to heal itself