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Inhibition of radiation-induced DNA-protein cross-link repair by glutathione depletion with L-buthionine sulfoximine

This present study and earlier work on AD have helped us to initiate a major clinical research program (ASHA) for blood based novel biomarker development for AD and PD

Expected phenotype Reduced GSH, oxidative damage Human disease relevance Involved in liver disease, neurodegeneration Model applications Glutathione metabolism, antioxidant defense Keywords: GSH synthesis, Oxidative stress, Detox Availability & Delivery: Cryo-recovery using in-house SOPF facilities Worldwide delivery by professional breeders

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An important role for glutamate excitotoxicity in the etiology of the illness is being supported by mounting evidence