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In conclusion, ammonia-induced cell death represents a distinct mode of cellular demise caused by ammonia accumulation, overlapping with and interacting with apoptosis, autophagy, necrosis, and other forms of cell death

Acknowledgements This study was supported, in part, by the National Key Research and Development Program of China (2017YFC1308900, 2018YFC1313300), Natural Science Foundation of Guangdong Province (2014A030312015, 2017A030313485)