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In contrast, neutral conditions (pH 7.4) exhibited minimal ion release (8.5%) (Fig

Future research should actively focus on preclinical evaluations using large animal models, such as pigs, dogs, and non-human primates, systematically assessing the safety, pharmacokinetic characteristics, and therapeutic effects of exosome therapies under more human-like anatomical and physiological conditions

The plasma is then reinjected into the patient along with a 5% albumin solution to compensate for lost protein concentration

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doi: 10.1016/j.molmed.2011.03.001

Insert the needle at a slight angle into the subcutaneous tissue