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202 However, after the end of treatment with diazoxide and alkylating agents, tumors in this group grew faster than in controls

(5) glucose dysregulation suppresses the expression of antioxidant genes via the Nrf2/ARE pathway, weakening the antioxidant defense and DNA repair capacity of the p53 pathway (48, 49)

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After incubation, the cells were washed twice with Dulbeccos phosphate-buffered saline (DPBS) and loaded with either 20 M DCFH-DA solution or 10 M DAF-FM DA reagent

Indeed, the activation of the NF-B pathway leads to the production of prostaglandins and the development of oxidative stress [85]

Starting at 1.0 mg significantly increases the risk of nausea, vomiting, and other gastrointestinal side effects