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One study raised an interesting point: circadian clock-related gene expression may exist in the pituitary, and this expression is related to the expression of GH gene ( CLOCK gene and the BMAL1 gene was not high, which was consistent with the view that different parts of the circadian clock system linked to different functions as circadian oscillators ( CLOCK, PER1, PER2, CRY3, NRLD2 ) showed the difference of expression oscillation in the pituitary of GH transgenic and wild type coho salmon, which indicated that the GH gene might have a regulatory effect on the expression of pituitary clock genes

10.1016/S1002-0160(08)60039-9 149 YabutaY.MotokiT.YoshimuraK.TakedaT.IshikawaT.ShigeokaS

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Furthermore, Tregs promote angiogenesis indirectly by restraining the activity of T H 1 cells and by triggering the activation of M2-like macrophages 42