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Cytochrome c, Apaf-1, d-ATP/ATP, and procaspase-9 interact to form an apoptosome, which then triggers the caspase cascade (Wang and Youle, 2009)

Antimicrobial Agents Chemother

10.1016/s0168-8227(11)70012-2 46 DanielJ

Possible mechanisms include abnormal iron metabolism dysregulation, lipid peroxidation, System Xc impairment, oxidative stress, transcription factors, ER stress, and glial cells (Fig

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Reported reactions include injection-site redness/itch, transient flushing and histamine-type reactions