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The Rb-E2F1 axis regulates the expression of BNIP3 in the hypoxic GBM TME, as mentioned above BNIP3 is essential for hypoxia-mediated protective autophagy [138]

At 208 weeks, semaglutide was associated with mean reduction in weight (10.2%), waist circumference (7.7 cm) and waist-to-height ratio (6.9%) versus placebo (1.5%, 1.3 cm and 1.0%, respectively

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These perhaps most significant findings regarding DSIP have been confirmed in other studies, which have shown that DSIP improves sleep structure and efficiency, and reduces sleep latency in chronic insomnia compared to placebo