does heavy drinking deplete glutathione in liver GSH Help Protect the Liver? Chronic Glutathione Depletion Confers Protection

Do not double the dose to compensate

Over-dilution (too much water) increases oxidative exposure surface area

Glutathione may interact with certain medications metabolized via glutathione conjugation, and excessive antioxidant activity can theoretically blunt beneficial inflammatory signaling during metabolic adaptation

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Furthermore, to mitigate the influence arising from energy disparities, their overall energy content was essentially equated in the final analysis (~600 kJ)

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