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Hypothesis of cellular plasticity [160] relate the neurotrophic and the neurogenic hypothesis to the statement that depression can be generally caused by damaged cellular plasticity leading to inadequate relations between structure and function
In this way, NRF2 drives the expression of various enzymes and signaling proteins involved in drug metabolism, antioxidant defense, and oxidative signaling, playing a crucial role in managing cellular responses to oxidative stress [7]
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