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While MPHs US Food and Drug Administration (FDA) label does not contain pharmacogenomic biomarkers, a lot of research has been performed on the impact of genotype on MPH efficacy, and several biological pathways have been suggested to potentially affect MPH mechanisms through patient genotype, mostly concerning monoamine pathways [4348]

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Sakihama et al., 2002)

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Low potassium may also contribute to worsening of the kidney failure