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Specifically, -MSH has exhibited potent anti-inflammatory and protective effects both in vitro and in vivo, impacting various pathways involved in inflammation regulation and protection

Similarly, further cellular and molecular experiments are needed to validate whether key genes in the prognostic model, such as MARCHF4, can serve as potential therapeutic targets

This is what happens also in obesity and its related hepatometabolic comorbidities, including NAFLD progression to NASH (see below)