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10.1017/S0954422419000301 10 BrownE

In thalassemia patients, the dysregulation of the glutathione antioxidant system can exacerbate the effects of iron overload

Ongoing and future research will be limited by the heterogenous nature of the study population and the lack of pre-phenotyping of mucus characteristics to pre-define an ideal mucolytic regimen

Clinically Relevant Experimental Animal Models Because of the limitations/difficulties related to human studies due to in part to ethical concerns, the use of experimental animal models becomes an important alternative to investigate disease pathogenesis

Cunningham AL et al