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Inflammatory responses induce the production of reactive oxygen species (ROS), which regulate the expression of proinflammatory cytokines such as IL-1, IL-6, and TNF- and subsequently activate the nuclear transcription factor-B (NF-B) pathway 38,39

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In another example, the coordination of the stress response between the mitochondria and cytosol is associated with an increase in fatty acid synthesis and in a decrease in ceramide synthesis in mitochondria, which promotes the expression of the molecular chaperone Hsp70 in the cytosol (Kim et al., 2016)

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elegans 18,33 , we observe that 24 h of fasting in early adulthood was sufficient to extend median lifespan by 40.8% (Fig

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