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ONC201 demonstrates antitumor effects in both triple-negative and non-triple-negative breast cancers through TRAIL-dependent and TRAIL-independent mechanisms

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Using biochemical assays, kinetic analysis, and molecular docking studies, we demonstrated that the dimer form exhibits superior binding affinity and inhibitory potency compared to both the monomer form and the reference inhibitor, ethacrynic acid

For PITC, on the other hand, the initial reaction of PITC and a model thiol is slower (Fig
