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Animal experiments The care and use of the animals were followed the animal welfare guidelines, and all the experimental protocols were approved the committee of Kobe University

Pinellia is often used in the treatment of peptic ulcers (Zhu et al., 2021), sleep disorders ( pinellia can alleviate inflammatory infiltration, restore alveolar structure, reduce collagen deposition, and decrease hydroxyproline content in lung tissue of mice with PF( pinellia decoction, which provides direction for further investigation into the pharmacodynamic molecules of pinellia ( pinellia , exhibit therapeutic effects on PF( 2+ concentration, thus achieving an anti-PF effect (Zhao et al., 2020)