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Moreover, kynurenine competes with other amino acids, such as methionine and leucine, that are transported by Slc7a5 to T cells, thereby impairing T cell-mediated immune responses [284]
Dedicated safety-pharmacology studies covering cardiovascular (including hERG/QT), respiratory, and central-nervous-system function
Improving liver and kidney function
First, we employed a series of fluorescent ROS indicators to assess changes in the mediators of oxidative stress (Supplementary Fig
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Huth ME, Ricci AJ, Cheng AG (2011) Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection
