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The biomarker clusters with increased lactate, pyruvate, alanine, and sometimes tricarboxylic acid cycle (TCA) intermediates (Figure 5, group 1), suggest dysfunction of oxidative phosphorylation or the TCA cycle

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Insulin controls postprandial liver metabolism by increasing de novo lipogenesis (DNL), suppressing fatty acid oxidation (FAO), and promoting triglyceride (TAG) esterification and secretion (173)

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