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A substantial body of clinical evidence accumulated over the past two decades, consistently demonstrates that NSW is able to significantly suppress endogenous melatonin secretion, as measured through urinary and salivary metabolites, primarily aMT6s and 6-hydroxymelatonin sulfate (6-OHMS) 171

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335,336 In addition to influencing the pharmacokinetics and pharmacodynamics of those anticancer drugs, the question of whether CYP2C8 polymorphism affects the occurrence and development of tumors is also very important

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