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The purified enzyme was completely inactive in the presence of molecular oxygen and the respective crystal structure revealed a substantial rearrangement of the active site loop region

Under pathological conditions, the excessive accumulation of liver-derived carnitine/acylcarnitine can also trigger a series of adverse events

Science 370 (6514), 364368

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While two DBPCS studies demonstrated LCs positive role in treating depression (evidence level 2a and 2b), and one study indicated improvements in ADHD symptoms in children (evidence level 2b), more research is warranted to provide conclusive recommendations