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As mitochondrial dysfunction is a key characteristic of a plethora of diseases, attempts to elucidate the crosstalk between mitobiogenesis and mitophagy will advance our understanding of the etiology and the development of novel therapeutic approaches for a variety of diseases

Further research may shed more light on the complex relationship between B12 and metabolism

In addition to alanine, a standard blood biomarker in MDs (Shaham et al., 2010), patients with primary mitochondrial respiratory chain disease also have significantly elevated levels of BCAAs (Vockley and Ensenauer, 2006)

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Therefore, NNMT can predict chemotherapy efficacy and represents a potential antitumor target

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