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10.1111/j.1476-5381.2011.01480.x Br

Shortt J, Johnstone RW (2012) Oncogenes in cell survival and cell death

doi: 10.1007/s00018-022-04389-w 138 BattisKXiangWWinklerJ

Louis MO, USA) were first administered with Cytoxan at a concentration of 25 mg/kg for one day followed by three days of Adriamycin that was prepared in H 2 O and given at a concentration of 1.5 mg/kg

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Method of Residual The value for k a cannot be obtained directly from the plasma-level time curve for the drug administered by oral route as we calculated the elimination rate constant (k), but it could be obtained using the method of residuals or a feathering technique, which is illustrated in the following graph: On a semilog paper, plot the relation between plasma drug concentrations versus time