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This article examines the mechanisms of cellular senescence, its role in cancer treatment, and the importance of senotherapy, with particular attention to the therapeutic potential of senolytic drugs

The compound's selectivity profile minimizes concerns about off-target effects, but investigators should consider potential interactions with other NAD+-modulating interventions or compounds that affect methylation metabolism

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Under-Dilution: Leads to a higher concentration, making precise dosing difficult

DNA Repair: When cellular DNA is damaged, repair enzymes (PARPs) require a large amount of NAD+ to complete the repair work and maintain gene stability
