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The first report of oral MA was published by Schneider and coworkers (1981) [3]
The nevi were assessed clinically and dermoscopically using ABCD rule and if found benign, were excised using shave excision

Interleukin (IL)-1 alpha- and -1 beta-, IL-6-, and tumor necrosis factor-alpha-like immunoreactivities in human common and dysplastic nevocellular nevi and malignant melanoma

For example, a 1996 pilot Phase I study documented increased pigmentation together with nausea, fatigue, yawning, and spontaneous erections in a small group of male volunteers

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PT-141 generally does not darken skin
