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References Lynch DR, Schadt K, Kichula E, McCormack S, Lin KY

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Clinical Takeaway Post-exertional malaise can significantly impair physical and cognitive function and may persist despite treatment for multiple conditions

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Mechanism of Action The mechanism of action of BPC-157 relies on several interconnected biological pathways

In simplified terms: BPC-157 Enhanced VEGFR2 signalling PI3K activation Akt activation eNOS phosphorylation Increased NO production This increased nitric oxide production leads to: Relaxation of vascular smooth muscle Arterial dilation Increased tissue perfusion Why This Matters Improved blood flow means: More oxygen delivery More nutrient transport Faster waste removal Better inflammatory resolution In injury models, increased perfusion strongly correlates with improved healing rates