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It can sense biochemical changes and act as a paracrine regulator of cardiomyocyte function, secreting nitric oxide (NO), endothelin, and prostacyclin [26]

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Multiple genes on Hsa21 and other genome sites, as well as epigenetic, environmental, and stochastics factors, are known to contribute to the clinical features of the syndrome

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The lymphocyte typing (T cells, T CD4+ cells, T CD8+ cells, B cells, natural killer cells) was performed on whole blood using BD FACSCanto II flow cytometry (BD Biosciences) and analyzed with BD FACSDiva software (BD Biosciences)