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Table 4 summarizes the important interactions of the BM TR with the subsites and the most recurrent amino acid contacts

The increased levels of aconitate decarboxylase 1 result in diversion of cis -aconitate away from the TCA cycle via its metabolism to itaconate

for vitamin B2, focus on free riboflavin, FAD, and FMN

Combining these antioxidants can provide comprehensive protection against oxidative stress and aging

10.1016/j.cell.2016.12.012 2

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