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Thus, even by prolonged fasting, the glucose levels that cancer cells are exposed to are not expected to fall below ~12 mmol/l, a range of values that has been verified by using glucose-sensing bacteria engineered to express GFP, embedded at different depths within solid tumors 56

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Moreover, it was reported that supplementing the diet with the antioxidants N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression (Sayin et al., 2014)

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